When I talk about the pain and hardship of a scientist's life, I'm speaking of more than existential angst. Galileo's work was condemned by the Church; Madame Curie paid with her life, a victim of leukemia wrought by radiation poisoning. Too many of us develop cataracts. None of us gets enough sleep. Most of what we know about the universe we know thanks to a lot of guys (and ladies) who stayed up late at night.