A successful unification of quantum theory and relativity would necessarily be a theory of the universe as a whole. It would tell us, as Aristotle and Newton did before, what space and time are, what the cosmos is, what things are made of, and what kind of laws those things obey. Such a theory will bring about a radical shift - a revolution - in our understanding of what nature is. It must also have wide repercussions, and will likely bring about, or contribute to, a shift in our understanding of ourselves and our relationship to the rest of the universe.