The true worth of an experimenter consists in his pursuing not only what he seeks in his experiment, but also what he did not seek.
Our ideas are only intellectual instruments which we use to break into phenomena; we must change them when they have served their purpose, as we change a blunt lancet that we have used long enough.
In teaching man, experimental science results in lessening his pride more and more by proving to him every day that primary causes, like the objective reality of things, will be hidden from him forever and that he can only know relations.
To be worthy of the name, an experimenter must be at once theorist and practitioner. While he must completely master the art of establishing experimental facts, which are the materials of science, he must also clearly understand the scientific principles which guide his reasoning through the varied experimental study of natural phenomena. We cannot separate these two things: head and hand. An able hand, without a head to direct it, is a blind tool; the head is powerless without its executive hand.
A discovery is generally an unforeseen relation not included in theory.
The doubter is a true man of science: he doubts only himself and his interpretations, but he believes in science.
First causes are outside the realm of science.
The science of life is a superb and dazzlingly lighted hall which may be reached only by passing through a long and ghastly kitchen.
I do not ... reject the use of statistics in medicine, but I condemn not trying to get beyond them and believing in statistics as the foundation of medical science. ... Statistics ... apply only to cases in which the cause of the facts observed is still [uncertain or] indeterminate. ... There will always be some indeterminism ... in all the sciences, and more in medicine than in any other. But man's intellectual conquest consists in lessening and driving back indeterminism in proportion as he gains ground for determinism by the help of the experimental method.
In science, the best precept is to alter and exchange our ideas as fast as science moves ahead.
We must never make experiments to confirm our ideas, but simply to control them.
The eloquence of a scientist is clarity; scientific truth is always more luminous when its beauty is unadorned than when it is tricked out in the embellishments with which our imagination would seek to clothe it.
When entering on new ground we must not be afraid to express even risky ideas so as to stimulate research in all directions. As Priestley put it, we must not remain inactive through false modesty based on fear of being mistaken.
Ardent desire for knowledge, in fact, is the one motive attracting and supporting investigators in their efforts; and just this knowledge, really grasped and yet always flying before them, becomes at once their sole torment and their sole happiness. Those who do not know the torment of the unknown cannot have the joy of discovery which is certainly the liveliest that the mind of man can ever feel.
Hatred is the most clear- sighted, next to genius.
The investigator should have a robust faith - and yet not believe.
Science admits no exceptions; otherwise there would be no determinism in science, or rather, there would be no science.
Theories are like a stairway; by climbing, science widens its horizon more and more, because theories embody and necessarily include proportionately more facts as they advance.
The great experimental principle, then, is doubt, that philosophic doubt which leaves to the mind its freedom and initiative, and from which the virtues most valuable to investigators in physiology and medicine are derived.
The stability of the internal medium is a primary condition for the freedom and independence of certain living bodies in relation to the environment surrounding them.
Proof that a given condition always precedes or accompanies a phenomenon does not warrant concluding with certainty that a given condition is the immediate cause of that phenomenon. It must still be established that when this condition is removed, the phenomen will no longer appear.
The mental never influences the physical. It is always the physical that modifies the mental, and when we think that the mind is diseased, it is always an illusion.
A great discovery is a fact whose appearance in science gives rise to shining ideas, whose light dispels many obscurities and shows us new paths.
Put off your imagination, as you put off your overcoat, when you enter the laboratory. Put it on again, as you put on your overcoat, when you leave.
Experiment is fundamentally only induced observation.
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