If you start parsing the cause-and-effect chain backward through time, eventually you land in cosmology - does the story begin with the Big Bang or the out-of-nothing creation of the world by the word of a Southern Baptist god? And that question is even more fraught than any of the others. The stakes couldn't be any higher, because not it's not just a question of life and death, but also a question of life after death or eternal torture after death.